It is kind of ironic that the last post talked about malaria. This post will talk about the vaccines for malaria and ebola. The new ebola vaccine is apparently quite effective which is a relief with such a scary disease. The malaria vaccine is effective but not as much as had been hoped for.
Interestingly, this vaccine won’t be given to travelers. It was designed for children of affected regions. This would be Africa, Pakistan and India, the primary places where 80-100% of the people are at risk of contracting malaria. Almost 600,000 people die a year from malaria, mostly kids under 5 from sub Saharan Africa.
The problem is that four shots are needed. Without the final booster shot administered 20 months after the first three shots, you might just as well not bother. There is no significant difference. With the booster shot, severe malaria cases decreased by about a third. Not ideal, but far better than nothing.
The other problem is the timing. It was found that it was more effective done a bit later and not at the same time that the children got their other vaccine shots. This will create a logistical nightmare for giving the shots. It also means that the youngest children who are very susceptible will not be protected.
Anthropologists have found that in areas with high malaria, the population was more spread out, there were fewer beasts of burden and the people were never able to organize into a more advanced civilization. Rather amazing that one parasite can have such an effect. Modern technology is helping some and even something as simple as bed netting can be as effective or more so than the vaccine. Will the two of them combined help to bring sub Saharan Africa into the 21st century?
The malaria vaccine has been worked on for 30 years and is the first human vaccine against a parasite. The Ebola vaccine was essentially developed 10 years ago and then just sat.
The problem is that vaccines are just as expensive to take through the regulatory process but little or no money is made on them. The only reason that the Ebola vaccine that was developed 10 years ago is getting out now is because of the recent Ebola outbreak. If the vaccine had come out when it was developed, it would have saved the lives of thousands of people in this recent outbreak. Recent tests have shown it to be extremely effective.
A proposal has been made to create an international fund to support vaccine research and to pay for the regulatory approval process. Countries and drug companies would contribute. The amount of money sought is around $2 billion dollars which may seem like a lot, but considering the cost of clinical trials isn’t that much. Also when you consider that fighting the recent Ebola outbreak cost over $10 billion, it would be an investment that was well worth it.