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An enzyme linked immunosorbent assay (ELISA) for the detection and semiquantitation
of anti-mitochondrial antibodies (AMA) in human serum. The presence
of AMA can be used as an adjunct to clinical and other laboratory findings in the
diagnosis of primary biliary cirrhosis.
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Company:
Date:
January 22, 2009
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100 assays. Cytochrome c has been shown to play an important role in apoptosis. The protein is located in the space between the inner and outer mitochondrial membranes. An apoptotic stimulus triggers the release of cytochrome c from the mitochondria into the cytosol where it binds to Apaf-1. The cytochrome c/Apaf-1 complex activates caspase-9 which then activates caspase-3 and other downstream caspases. The Cytochrome c Releasing Apoptosis Assay Kit provides an effective means for detecting cytochrome c translocation from mitochondria into cytosol during apoptosis. The kit provides an easy-to-
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Company:
Date:
January 22, 2009
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Category Name: Autoimmune Disorders
Method: ELISA
Principle: ELISA
Controls Standards: Positive, Negative and Calibrator
Sensitivity: Not available
Sample: 100 µl
Runtime: 50 Minutes
Wavelength: 450 nm
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Company:
Date:
January 22, 2009
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MitoLight® Mitochondrial Apoptosis Detection Kit
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Company:
Date:
January 22, 2009
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A kit of antibodies, one against each of the 5 OXPHOS complexes and PDH. MitoProfile® Kit MS602 contains a total of 220 µg of mAbs , each provided in 50 µl aliquots at a 200x working concentration. The individual mAbs were chosen because they are against a subunit labile when its complex is not assembled and because they work well in immunocytochemistry. The mAbs are against CI-NDUFB4, CII-30kDa, CIII-Core protein 2, CIV-subunit I, CV-OSCP and PDH E1 α subunit respectively. (CI-NUDFB4 was previously listed as likely CI-NDUFA6).
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Company:
Date:
January 22, 2009
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100 ug of monoclonal antibody reactive against nicotinamide nucleotide transhydrogenase (NNT). NNT is a mitochondrial inner membrane protein catalyzing the interconversion of NADH and NADPH within the matrix space of the organelle which has crucial roles in oxidative stress
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Company:
Date:
January 22, 2009
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100 ug of monoclonal antibody reactive against the mitochondrial trifunctional protein (TFP). TFP is part of the mitochondrial fatty acid beta-oxidation pathway. It is located in the inner mitochondrial membrane and it catalyzes three out of the four steps in the beta-oxidation cycle with a specific affinity for long chain substrates. Inherited deficiency of TFP is a recessive genetic disease which occurs in approximately 1:38,000 newborns in the US. Deficiency of LCHAD (the dehydrogenase part of TFP) has also been found in children of women who develop HELLP syndrome (1:1,000 pregnancies) and
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Company:
Date:
January 22, 2009
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100 µg of monoclonal antibody against mitofilin, suitable for use in western blotting and immunocytochemistry. Isolated mitochondria are available from several species for use as control samples. To see the complete list of control samples available from MitoSciences
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Company:
Date:
January 22, 2009
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Mitochondrial Antibody
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Company:
Date:
January 22, 2009
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Cytochrome c has been shown to play an important role in apoptosis. The protein is located in the space between the inner and outer mitochondrial membranes. An apoptotic stimulus triggers the release of cytochrome c from the mitochondria into the cytosol where it binds to Apaf-1. The cytochrome c/Apaf-1 complex activates caspase-9 which then activates caspase-3 and other downstream caspases. The Cytochrome c Releasing Apoptosis Assay Kit provides an effective means for detecting cytochrome c tra
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Company:
Date:
March 03, 2009
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