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Aldosterone produced in the adrenal cortex, is the most potent mineralcorticoid in humans. As with other steroid hormones, aldosterone is synthesized from cholesterol through a series of enzyme-mediated steps. Aldosterone and cortisol differ only in that a hydroxyl modification occurs at the 18, rather than 17, position on the steroid molecule.
The first and rate-limiting step in steroidogenesis, conversion of cholesterol to pregnenolone, is stimulated by adrenocorticotropic hormone (ACTH). However, ACTH has only a minimal effect on aldosterone production. Aldosterone secretion appears to be
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December 15, 2008
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Aldosterone Tests
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Date:
December 15, 2008
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ImmunotechDirect assay on coated-tube format:
Robustness, practicability and possible automation of the assay.
♦ Convenient with a small sample volume, a short incubation time and a wide
calibrator range.
♦ No extraction of urine samples before assay (simple hydrolysis).
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Company:
Date:
December 15, 2008
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