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The bladder tumor associated antigen has been shown to be produced by bladder tumor cells in cell culture and shed into the urine of bladder cancer patients where it can be detected using the BTA stat Test and/or BTA TRAK Assay. It has also been shown to be produced by bladder tumor cells using in situ hybridization. In addition, cultured cells, inlcuding bladder cancer cells, have been shown to be significantly more susceptible to lysis by complement in the presence of monoclonal antibodies specific for FH/CFHrp.
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