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The measurement of RF is important in the diagnosis and prognosis of rheumatoid arthritis, as high titers of RF occur in sera of patients who tend to develop extraarticular complications1,2. The majority of routine laboratory tests measure IgM RF by its ability to agglutinate sheep red blood cells, latex or similar particles coated with IgG1-4. However, recent studies suggest that RF of other immunoglobulin isotypes is also present in rheumatoid arthritis and other disorders5-10.
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