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Common disease and can affect between one in three hundred to one in two thousand
adults depending on the country. Gliadin is a mixture of around 50 components and has a
molecular weight of 16-40kD. Gliadin can be divided into four major fractions according
to electrophoretic mobility. Studies have shown that these fractions as well as prolamins
contained in barley, oats and rye have toxic effects on patients with Coeliac disease.
In Coeliac disease the destruction of the gut villous structure increases the permeability of
the absorptive area to macromolecules. This leads to increased antibody
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