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Rheumatoid autoimmune diseases are often associated with the occurence of autoanti-bodies against several nuclear or cytoplasmatic antigens. In patients with Sjögren-Syndrome antibodies against SS-A and SS-B often occur in combination. The anti SS-A protein passes the placenta and may cause the development of SLE in neonates. Each class of immunoglobulins causes a specific immunofluorescent pattern.
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