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Vacuum-driven liquid processing facilitates sample handling and reduces hands-on preparation time by eliminating the tedious loading and unloading of spin columns into a centrifuge and subsequent removal of flow-through during binding and washing procedures (see flowchart). Prevention of cross-contamination is especially critical when purifying nucleic acids from clinical samples. QIAGEN spin columns are inserted into disposable VacConnectors, preventing direct contact of the spin column with the manifold. VacValves ensure constant vacuum pressure with viscous samples like blood. The QIAvac 24
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